Discovering repurposable drugs for Alzheimer&#39;s disease and related dementias: target trial emulation using decentralised real-world data.

propranolol - Generic mfg.

tizanidine - Generic mfg.

gabapentin - Generic mfg.

epinephrine - Generic mfg.

dexamethasone - Generic mfg.

fluconazole oral - Generic mfg.

famotidine - Generic mfg.

ezetimibe - Generic mfg.

celecoxib oral - Generic mfg.

Jardiance (empagliflozin) - Eli Lilly, Boehringer Ingelheim

cefazolin - Generic mfg.

prednisone - Generic mfg.

spironolactone - Generic mfg.

pregabalin - Generic mfg.

ketorolac - Generic mfg.

Discovering repurposable drugs for Alzheimer's disease and related dementias: target trial emulation using decentralised real-world data. (PubMed, EBioMedicine) - Sep 5, 2026 - "20 widely used medications may be associated with reduced progression from MCI to ADRD and represent promising candidates for clinical evaluation as repurposed therapies for dementia."
Journal • Real-world evidence • Alzheimer's Disease • Cardiovascular • CNS Disorders • Cognitive Disorders • Dementia • Pain

http://www.ncbi.nlm.nih.gov/pubmed/42697072

Bingyu Zhang; David A Wolk; Dazheng Zhang; Fei Wang; Fongci Lin; Haoyang Li; Hua Xu; Huilin Tang; Jiang Bian; Jiayi Tong; Kyra S O'Brien; Lu Li; Maxwell Salvatore; Na Hong; Qiong Wu; Ruowang Li; Siqi Chen; Ting Zhou; Tingyin Wang; Yiwen Lu; Yong Chen; Yu Hu; Yu Huang; Yujia Zhou; Yuqing Lei; Zhenxing Xu

Sep 5, 2026