DECREASE study: A European pool-analysis of patients with significant reductions in concomitant antiseizure medications in cenobamate Early Access Programs. (PubMed, Epilepsia Open) - Aug 22, 2026 - "People with highly drug-resistant epilepsy often need to take several antiseizure medications at the same time. Combined data from European Early Access Programs show that about 10% of people treated with cenobamate were able to stop all other antiseizure medications or reduce treatment to cenobamate plus one other medication. Despite this simplification of treatment, one-third of these patients became seizure-free and more than two-thirds experienced at least a 50% reduction in seizure frequency. Within this group, no patients stopped cenobamate because of side effects."
Journal • CNS Disorders • Epilepsy • Fatigue • Otorhinolaryngology • Vertigo
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Andreas Schulze-Bonhage; Antonio Gambardella; Asier Gomez-Ibañez; Bernhard J Steinhoff; Dániel Fabó; Edoardo Ferlazzo; Elena Tartara; Francesca Felicia Operto; Giovanni Boero; Gustavo Torres-Gaona; Hester Garratt; Javier Peña-Ceballos; Juan Rodriguez-Uranga; Kevin Hampel; Laura Canafoglia; Nicola Specchio; Norman Delanty; Patrick B Moloney; Rainer Surges; Randi von Wrede; Rhys H Thomas; Roberta Roberti; Simona Lattanzi; Vicente Villanueva; Yulia Novitskaya; Zsófia Jordán
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