Cenobamate and Trazodone Combination Suppresses Seizures, EEG Alterations, Preserves Neuronal Architecture and Normalizes the BDNF/TrkB Expression in PTZ‑Kindled Mice. (PubMed, Neurochem Res) - Aug 15, 2026 - "Therefore, we investigated the effect of cenobamate (CNB, 30 mg/kg) and trazodone (TZ, 10 mg/kg), alone and in combination, in PTZ-kindling model, where mice received 11 doses of pentylenetetrazole (PTZ, 40 mg/kg) every other day for three weeks. These parallel findings suggest that positive allosteric GABAA modulation and persistent sodium-current inhibition by CNB, combined with TZ serotonergic modulation, reduce hyperexcitability, pathological neuroplasticity, and glial reactivity. Collectively, TZ + CNB is a promising mechanistically complementary regimen that suppresses seizure progression and associated molecular and neurostructural pathology, which needs further preclinical optimization and translational investigations."
Journal • Preclinical • CNS Disorders • Epilepsy • BDNF • GFAP • NTRK2
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Fakhir Hannan; Faleh Alqahtani; Imran Imran; Khaled Ahmed Saghir; Saleh A Alqarni; Syed Muhammad Muneeb Anjum; Waleed Shakeel; Waseem Ashraf
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