'Weak by Structure'-Limb Muscle Fibre Cytoarchitecture Remodelling During Critical Illness and Effects of Chaperone Co-Inducer BGP-15 and Dissociative Glucocorticoid VBP-15. (PubMed, Cells) - Jul 14, 2026 - "VBP-15 reversed atrophy at day 10 in soleus but not in EDL fibres. Our study is the first to quantify myofibrillar remodelling in limb muscle fibres during ICU intervention in 3D and provides exploratory assessment of BGP-15 and VBP-15 treatments on aberrant remodelling in CIM."
Journal • Critical care • Muscular Atrophy • Myositis • CEACAM1
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Anette Wirth-Hücking; Dominik Schneidereit; Julian Bauer; Lars Larsson; Lucas Kreiß Roohian; Michael Haug; Nicola Cacciani; Oliver Friedrich; Sebastian Schürmann; Sofia Mnuskina; Stefanie Nübler
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