Exploring the Role of Early Add-On Cenobamate in Uncontrolled Focal Epilepsy: A Critical Appraisal of the Evidence. (PubMed, Neurol Ther) - Jul 10, 2026 - "Cenobamate may offer substantial benefit in adults with uncontrolled focal epilepsy, with a favorable efficacy-tolerability balance, high retention, and possible advantages when introduced earlier (after two ASMs). Its interaction profile underscores the importance of careful management of concomitant ASMs. Because the comparative signals derive largely from non-randomized data, prospective controlled research is needed to confirm any benefit of early use and to better characterize long-term cognitive and psychiatric effects."
Clinical • Journal • Review • CNS Disorders • Epilepsy • Psychiatry
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Alfonso Iudice; Carlo Andrea Galimberti; Carlo Di Bonaventura; Giancarlo Di Gennaro; Simona Lattanzi
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