Substitutions M478K and A482G in the polymerase of yellow fever virus confer resistance to sofosbuvir and uprifosbuvir in vitro.

galidesivir (BCX4430) - BioCryst Pharmaceuticals

bemnifosbuvir (AT-527) - Atea Pharma

uprifosbuvir (IDX21437) - Merck (MSD)

remdesivir - Generic mfg.

Sovaldi (sofosbuvir) - Gilead

http://www.ncbi.nlm.nih.gov/pubmed/41765050

Alekxander Binderup; Alina Soto; Ana Lucia Rosales Rosas; Itsaso Ortigosa Elorz; Jens Bukh; Leen Delang; Line Abildgaard Ryberg; Lotte Mikkelsen; Santseharay Ramirez; Ulrik Fahnøe

Mar 2, 2026