ARD-101, a gut-restricted TAS2R agonist, reduces hunger in adults and promotes weight loss in DIO mice with DPP-4 inhibition.

Zepbound (tirzepatide) - Eli Lilly

Januvia (sitagliptin) - Merck (MSD)

ARD-101 - Aardvark Therap

http://www.ncbi.nlm.nih.gov/pubmed/41833222

Alexa Warner; Brad Hirakawa; Bryan Jones; Jeremy H Pettus; Jerlyn Tolentino; Justin Stege; Manasi Jaiman; Megan Pugsley; Tien-Li Lee; Timothy J Kieffer; Zhenhuan Zheng

Mar 16, 2026