Spared but Not Silent: Ion Channel Plasticity in Uninjured Sensory Neurons in Neuropathic Pain. (PubMed, Int J Mol Sci) - Sep 27, 2026 - "Here we review the ion channel alterations that sustain chronic pain states, the mechanisms by which neurons modulate expression of these channels, and the electrophysiological and functional consequences of these shifts in expression profile. We close by examining existing therapeutics directed at these channels and their regulatory mechanisms, which may offer means of interrupting the maintenance of neuropathic pain."
Journal • Review • Neuralgia • Pain
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Andrew Speidell; Kimberly Gómez; Rajesh Khanna
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