Human iPSC-Derived Trigeminal Ganglion Neurons Exhibit Robust NaV1.8 Function on Automated Patch Clamp and TRPV1 Activity for Pain Drug Discovery (Neuroscience 2026) - Sep 27, 2026 - Abstract #PSTR015.23 / Y13; Pres time: Nov 14, 2026; 01:00 PM - 05:00 PM; Location: WCC Halls A-C; "Recordings identified robust TTX-resistant sodium currents consistent with NaV1.8 activity that were inhibited by 30 nM Suzetrigine...Together, these results establish a reproducible human trigeminal neuron platform with consistent molecular identity, robust TRPV1 responsiveness, and functional NaV1.8 activity across independent manufacturing batches. This system provides a scalable tool for investigating trigeminal biology, migraine mechanisms, ion channel pharmacology, and pain therapeutic discovery."
CNS Disorders • Migraine • Pain • ADCYAP1 • ISL1 • NAV1 • TRPM8 • TRPV1
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V. TRUONG1; T. STRASSMAIER2; Y.-L. LU2; M. L. GRAY2; R. HAEDO2; P. WALSH1
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