Trikafta (elexacaftor/tezacaftor/ivacaftor) - Vertex
Ecological Patterns of Gut Microbiota During Elexacaftor/Tezacaftor/Ivacaftor Therapy in Cystic Fibrosis. (PubMed, Microorganisms) - Sep 27, 2026 - "Progressive depletion and transient changes or recovery of bacterial taxa may only represent a rough idea of the ecological changes in the gut microbiota observed during the course of ETI therapy. Longitudinally studies based on large cohorts of CF patients are mandatory to properly interpret these very preliminary results and to search for actual ETI-induced microbiome effects." 
Journal • Cystic Fibrosis • Genetic Disorders • Immunology • Pulmonary Disease • Respiratory Diseases • CFTR
http://www.ncbi.nlm.nih.gov/pubmed/42795633
 
Alessandro Fiocchi; Chiara Marangelo; Enza Montemitro; Ersilia Fiscarelli; Fabiana Ciciriello; Federica Del Chierico; Federico Alghisi; Francesca Toto; Lorenza Putignani; Luigia Turco; Matteo Scanu; Renato Cutrera; Valentino Bezzerri; Vincenzina Lucidi
 
Sep 27, 2026
 
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