Activation of CFTR Suppresses Calcium-cAMP Signaling and Cyst Growth in ARPKD (KIDNEY WEEK 2026) - Oct 2, 2026 - Abstract #FR-PO0092; Pres time: Oct 23, 2026; 10:00 AM - 12:00 PM; Location: Exhibit Hall A, Convention Center; "Methods In the present study WT (C57Bl/6) and ARPKD ( Pkhd1 del3-4/del3-4 ) mice models were used and treated with CFTR modulators (VX809 and VX445). Conclusion Overall, results showed that CFTR may act as a key player in intracellular Calcium & cAMP signaling which contributes to ARPKD cyst growth. Activating CFTR, rather than inhibiting it, may be a promising therapeutic way to limit ARPKD disease progression"
Hepatology • Polycystic Kidney Disease • PKHD1 • STIM1
|
|
Abhishek Sharma; Tanvi Sharma; Masoud Afshani; William B. Guggino; Liudmila Cebotaru
|