First-in-human phase 1/2 study of autologous T cells engineered using the Sleeping Beauty System transposon/transposase to express T-cell receptors (TCRs) reactive against cancer-specific mutations in patients with advanced solid tumors.

cyclophosphamide - Generic mfg.

Proleukin (aldesleukin) - Clinigen, Novartis, Prometheus

library TCR-T-cell therapy - Alaunos Therap

fludarabine IV - Generic mfg.

https://meetings.asco.org/abstracts-presentations/213447

Marcelo Vailati Negrao; Maria Pia Morelli; Amir A. Jazaeri; Benny Johnson; Partow Kebriaei; Drew Deninger; Eleanor De Groot; Matthew R. Collinson-Pautz; Nathan A. Demars; Jaymes S. Holland; John Heymach; Raffaele Baffa; Scott Kopetz

Apr 28, 2022