Evofosfamide Enhances Sensitivity of Breast Cancer Cells to Apoptosis and Natural-Killer-Cell-Mediated Cytotoxicity Under Hypoxic Conditions. (PubMed, Cancers (Basel)) - Jun 26, 2025 - "Evofosfamide is converted into bromo-isophosphoramide mustard, a potent DNA cross-linking agent that is expected to enhance the killing of cancer cells under hypoxic conditions, where these cells typically exhibit resistance. qPCR analysis revealed that Evofosfamide was capable of restoring type I interferon signaling in hypoxic breast cancer cells, leading to the subsequent cytolytic activity of NK cells against the tumor cells. Thus, conditioning the breast cancer cells with Evofosfamide resulted in enhanced cell killing under hypoxia, further underscoring its potential as a sensitizer to target hypoxia-driven tumors."
Journal • Breast Cancer • Oncology • Solid Tumor • CASP3 • CASP7
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Ayda Shah Mahmood; Goutham Hassan Venkatesh; Husam Hussein Nawafleh; Nagwa Ahmed Zeinelabdin; Raefa Abou Khouzam; Rania Faouzi Zaarour; Salem Chouaib; Shubhankar Das; Walid Shaaban Moustafa Elsayed
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