EXPLORING THE EFFICACY OF DIVERSE CHEMOTHERAPY AGENTS TO OVERCOME CISPLATIN RESISTANCE IN GERM CELL TUMOR CELL LINES (SIOP 2024) - Oct 2, 2024 - Abstract #ID 626; "Aim: To assess the in vitro efficacy of Ifosfamide, Azacytidine, Paclitaxel, and Carboplatin in cisplatin-resistant GCTs... Palifosfamide treatment resulted in a higher IC50 (1.6 fold, p ≤ 0.01) in NTERA-2R (210.8 μM) compared to NTERA-2P (135.3 μM)... Paclitaxel and Azacitidine demonstrated comparable responses in both cisplatin-sensitive and -resistant GCTs, suggesting their potential to restore chemotherapy sensitivity in vitro. These findings provide valuable insights into the behavior of cisplatin-resistant GCTs under different chemotherapy regimens."
Preclinical • Tumor cell • Embryonal Tumor • Germ Cell Tumors • Oncology • BRCA1
|
|
Bruna Inez Dos Santos Cruz 1; Vanessa Monteiro Oliveira 1; Marcela Nunes Rosa 1; Isabela Cristiane Tosi 1; Luiz Fernando Lopes 2; Mariana Tomazini Pinto 1
|