An evaluation of the combination effect of zoledronate and chemotherapeutic agents in canine osteosarcoma cells. (PubMed, Front Vet Sci) - Feb 29, 2024 - "Carboplatin, doxorubicin, vinorelbine, toceranib, and isophosphoramide mustard (active metabolite of ifosfamide) were used as chemotherapeutic agents. When zoledronate was used in combination with chemotherapy drugs, while it showed potential synergistic effects with toceranib, potential antagonistic effects with vinorelbine and isophosphoramide mustard were observed. However, the results differed by cell line and thus, further evaluation is warranted to understand the exact mechanism of action."
Journal • Musculoskeletal Pain • Oncology • Osteosarcoma • Pain • Prostate Cancer • Sarcoma • Solid Tumor
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Bruce F Smith; Noelle Bergman; Satyanarayana R Pondugula; Stephanie E S Lindley; Yoshimi Iwaki
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