Mitochondrial Dysfunction in Ifosfamide-Induced Nephrotoxicity: Mechanisms and Possible Interventions. (PubMed, Eur J Pharmacol) - Aug 20, 2026 - "Isophosphoramide mustard is the therapeutically active metabolite, whereas chloroacetaldehyde (CAA) is considered the nephrotoxic metabolite...To address this, we recommend investigating genetic susceptibility, and determining mitochondrial pathways, such as disrupted mitochondrial dynamics, mitochondrial DNA damage, and dysregulated energy signaling, through integrated molecular, functional, and metabolomic analyses in human-derived in vitro models. Additionally, we recommend evaluating nephroprotective strategies, including antioxidants, mitochondrial transplantation, and therapies that stimulate mitochondrial biogenesis, to identify interventions that prevent kidney injury while preserving antitumor efficacy."
Journal • Review • Chronic Kidney Disease • Metabolic Disorders • Nephrology • Oncology • Renal Disease • Solid Tumor • Transplantation
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Gerrit van den Berg; Gisela G Slaats; Jolita Ciapaite; Kate Liang; Marianne C Verhaar; Marry M van den Heuvel-Eibrink; Rosalinde Masereeuw
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