Erdosteine Provides Effective Analgesia in Inflammatory Pain Without Impairing Pain Resolution: A Preclinical Comparison With Non-Steroidal Anti-Inflammatory Drugs. (PubMed, Eur J Pain) - Jul 12, 2026 - "Effective and well-tolerated treatments for chronic pain remain limited. Erdosteine is a clinically approved mucolytic with antioxidant and anti-inflammatory properties whose analgesic potential is largely unexplored. We show that oral erdosteine reduces inflammatory pain and allodynia without delaying recovery, unlike the NSAID diclofenac, which increased systemic markers of inflammation and prolonged pain duration. These findings identify erdosteine as a promising candidate for drug repurposing and support further investigation of its potential utility in pain management."
Clinical • Journal • Preclinical • Inflammation • Neuralgia • Pain • Respiratory Diseases • CXCL1 • IL1R1 • S100A8 • S100A9
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Clive Page; Grace Yu; Lucas Vasconcelos Lima; Luda Diatchenko; Massimo Allegri; Mohamad Karaky; Nicoletta Marchesi; Stefano Govoni
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