Mucus Plugs in COPD and Cardiovascular Mortality: An Emerging Risk Pathway and the Therapeutic Potential of Mucolytic Strategies. (PubMed, Respir Med) - May 28, 2026 - "Among thiol-based mucolytics, erdosteine has been shown to reduce exacerbation frequency and duration...However, its comparative advantages over other agents remain uncertain. This narrative review summarizes the current evidence regarding the epidemiology, pathophysiology, and clinical implications of mucus plugging in COPD, with a focus on the proposed mucus plug-exacerbation-cardiovascular event axis and the potential role of mucus-directed therapies."
Journal • Review • Cardiovascular • Chronic Obstructive Pulmonary Disease • Immunology • Inflammation • Pulmonary Disease • Respiratory Diseases
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Luigino Calzetta; Maria Gabriella Matera; Mario Cazzola; Paola Rogliani; Vincenzo Parente
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