Dysregulated Proline Metabolism Exacerbates Hepatocellular Carcinoma Metastasis via EPRS1-Mediated mRNA Translation. (PubMed, Cancer Commun (Lond)) - May 19, 2026 - "Finally, the inhibitory effect of bersiporocin on HCC metastasis was confirmed in patient-derived orthotopic xenograft models. Our findings not only revealed the critical role of l-proline-bound EPRS1 in promoting HCC metastasis but also indicated that inhibiting this binding could be a promising strategy to prevent metastasis."
Journal • Hepatocellular Cancer • Oncology • Solid Tumor • EPRS1 • ITGB1 • PIK3CA
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Haibo Yu; Hongzhong Zhou; Hui Zhang; Juan Chen; Leirong Gu; Ming Tan; Shengtao Cheng; Tingting Gao; Wanjin Chen; Weixian Chen; Xiameng Su; Xinyan Chen; Zhiling Wang
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