Chlorogenic Acid Fails to Confer Neuroprotection in a Chronic Mouse Model of Parkinson's Disease. (PubMed, Mol Neurobiol) - Aug 28, 2026 - "Notably, CA elicited a modest reduction in microglial and astrocytic activation in female mice, highlighting a sex-dependent immunomodulatory response. Collectively, these findings reveal a clear dissociation between robust in vitro neuroprotection and limited in vivo efficacy in a chronic α-Syn-driven PD mouse model, emphasizing the importance of incorporating progressive disease paradigms and sex as a biological variable in preclinical therapeutic evaluation."
Journal • Preclinical • CNS Disorders • Inflammation • Movement Disorders • Parkinson's Disease
|
|
Akshaya Rajan; Devendra Singh; Poonam Thakur; Surya Prakash
|