Phytochemical Characterization of Tilia americana var. mexicana, Exploratory Study of MAO Molecular Docking and Evaluation of Behavior in Mice in a Reserpine-Induced Parkinson Model. (PubMed, Molecules) - Aug 28, 2026 - "Chemical analysis identified six terpenes: α- and β-amyrine (1-2), β-sitosterol (3), stigmasterol (4), ursolic acid (5), and β-sitosterol glucoside (6); the novel diglycosylated monoterpene 4α-terpineol sambubioside (7), characterized through its hexaacetate derivative (7a); the flavonoids tiliroside (8) and rutin (9); sucrose (10); and four phenolic compounds: scopoletin (11), caffeic acid (12), coumaric acid (13), and chlorogenic acid (14)...Overall, this study demonstrates that integrating phytochemical isolation, molecular docking, and in vivo pharmacological evaluation provides a useful strategy for prioritizing bioactive metabolites from T. americana. These findings support further pharmacological investigation of this medicinal species and its isolated metabolites, while additional studies are required to establish their molecular targets and mechanisms of action."
Journal • Preclinical • CNS Disorders • Movement Disorders • Parkinson's Disease
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Alejandro Zamilpa; Antonio Ruperto Jiménez-Aparicio; Blanca Eda Domínguez-Mendoza; Enrique Jiménez-Ferrer; Gabriela Trejo-Tapia; Manases González-Cortazar; Maribel Herrera-Ruiz; Maribel Osorio-García
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