Chlorogenic Acid Alleviates Heat Stress-Induced Fetal Growth Restriction Through Gut-Placental Crosstalk by Reshaping Gut Microbiota and Mediating Keap1-Nrf2 Antioxidant Signaling. (PubMed, Antioxidants (Basel)) - Aug 28, 2026 - "In summary, our study suggests that gestational HS exposure may trigger FGR through the gut-placenta axis. CGA effectively reverses FGR by restoring placental efficiency and placental barrier integrity, while alleviating maternal gut dysbiosis and intestinal barrier impairment. FMT experiments further confirm that the gut microbiota may play a key role in this protection. Collectively, these findings suggest that targeting the gut-placenta axis with CGA may offer a practical nutritional strategy to mitigate HS-triggered adverse pregnancy outcomes."
Journal • Transplantation • CLDN1 • OCLN
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Biyan He; Caixue Xu; Chang Yan; Chenjun Wang; Jiangong Li; Ning Liu; Siyu Wu; Yifei Zhang; Yiling Xiang; Yinghe Qin; Yingjie Wu; Yongtian Yin
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