Spatiotemporal synergistic drug co-delivery via a dual-crosslinked liposomal platform for potent NETs blockade in rheumatoid arthritis. (PubMed, Colloids Surf B Biointerfaces) - Aug 26, 2026 - "Herein, we developed a PGP-modified, lipid bilayer-crosslinked and nanogel-embedded liposomal platform (PLipoGel@CH) for effective co-delivering chlorogenic acid (CA, a ROS scavenger) and hydroxychloroquine (HCQ, a PAD4 inhibitor) to activated neutrophils. After intravenous injection, PLipoGel@CH leveraged the inflammatory tropism of neutrophils to accumulate in inflamed joints, and significantly attenuated inflammatory responses and histopathological damage by blocking NETs formation. By harmonizing the in vivo performance of synergistic agents, this spatiotemporal synergistic nanoplatform provides a potent strategy for RA treatment."
Journal • Immunology • Inflammation • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology • UGT1A1
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Fucheng Cai; Jianheng Ren; Qin Wang; Xianyan Qin; Xin Wen; Yaqiang Weng; Yingchun Zeng; Yuanyi Hua; Zhumei Liao
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