Chlorogenic acid inhibits intestinal lipid uptake and promotes adipose lipid catabolism via epithelium-derived exosomes in ob/ob mice. (PubMed, Front Physiol) - Aug 14, 2026 - "These exosomes reduced triglyceride levels and modulated the expression of lipid metabolism-related genes in 3T3-L1 cells. Collectively, our findings suggest that chlorogenic acid may exert metabolic benefits, at least in part, through a coordinated intestine-adipose axis and provide preliminary evidence supporting a potential role for exosome-mediated inter-organ communication in the regulation of lipid homeostasis."
Journal • Preclinical • Genetic Disorders • Metabolic Disorders • Obesity • PPARG
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Di Wang; Xu Zhou; Yifang Zhou; Yongwang Yan
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