T-cell activity feedback-guided photothermal immunotherapy enabled by immune-responsive redox nanodots. (PubMed, Mater Today Bio) - Aug 12, 2026 - "To address these challenges, an ultrasmall polychlorogenic acid nanodot platform, termed PCGA-ND, was developed via Fe3+ and TEMPO catalyzed oxidative polymerization of chlorogenic acid...Collectively, the strategy resulted in a tumor growth inhibition rate of 99.42% relative to control treatments in 4T1 tumor-bearing mice, accompanied by a more than 13-fold increase in intratumoral CD8+ T - cell infiltration. Overall, this work establishes a generalizable theranostic framework that couples photothermal therapy with immune responsive imaging and redox regulation, providing a practical strategy for improving immune preservation and therapeutic precision in photo immunotherapy."
Journal • Breast Cancer • Metabolic Disorders • Oncology • Solid Tumor • Thermal Injury • CD8 • GZMB
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Huan He; Jing Zhu; Jixi Zhang; Lin Li; Sheng Zhao; Yunyun Wu; Yuxin Jin; Zhenqiang Wang
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