In Situ Sonoafterglow Supramolecular Hydrogel From Natural Substrate for Post-Surgical Glioblastoma Treatment. (PubMed, Angew Chem Int Ed Engl) - Aug 1, 2026 - "This study pioneers the discovery that chlorogenic acid (CA), a natural antitumor agent, exhibits unique sonoafterglow properties...The VP@Pro‑CA gel formulation, which incorporates the sonosensitizer verteporfin (VP), allows post‑operative local injection for sonodynamic therapy (SDT) to prevent glioblastoma (GBM) recurrence. Crucially, the ONOO-‑triggered afterglow emission enables real‑time therapeutic monitoring, demonstrating exceptional potential for GBM theranostics. Notably, CA constitutes a novel class of biosafe, small‑molecule sonoafterglow substrates with intrinsic pharmacological activity, offering unparalleled advantages for clinical translation in this emerging field."
Journal • Brain Cancer • Glioblastoma • Oncology • Solid Tumor
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Bowen Fu; Hao Zhai; Minqian Luo; Shangfei Li; Ting Cai; Wei Long; Xiangyu Pei; Xiao Yu; Xiaoyi Zhang; Xuanshang Lu; Yayun Peng; Yin Wan; Yuhan Yang
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