A comprehensive review of coffee melanoidins: from structural characterization to biological activity. (PubMed, Crit Rev Food Sci Nutr) - Jul 31, 2026 - "This review provides a comprehensive analysis of the chemical architecture of coffee melanoidins, characterized by a unique polysaccharide-dominated skeleton (primarily arabinogalactans) integrated with proteins and phenolic compounds like chlorogenic acids...Emerging evidence highlights the diverse biological activities of coffee melanoidins, including potent antioxidant, anti-inflammatory, antimicrobial, and prebiotic effects, within others. This review underscores the role of coffee melanoidins as significant dietary bioactive components with the potential to modulate human physiology and prevent chronic metabolic and oxidative stress-related diseases."
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