Coffee as a polypharmacological modulator of mitochondrial health: from molecular mechanisms to translational implications. (PubMed, J Transl Med) - Jul 19, 2026 - "Collectively, these findings support the hypothesis that coffee may serve as a paradigm of polypharmacological dietary intervention that targets fundamental pathways of mitochondrial resilience. Moving beyond reductionist views centered on single compounds, we propose that the holistic effects of coffee are best understood through systems-level modulation of mitochondrial homeostasis. Future research should prioritize precision nutrition approaches stratified by genotype, microbiome, and metabolic phenotype, to translate these mechanistic insights into personalized dietary recommendations and the development of mitochondria-targeted nutraceuticals. We caution that this integrative framework requires direct validation in human causal studies."
Journal • Review • Alzheimer's Disease • Cardiovascular • CNS Disorders • Diabetes • Hepatology • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease • Movement Disorders • Parkinson's Disease • Type 2 Diabetes Mellitus • CYP1A2
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