A Screening-Guided Biomimetic Exosome-Liposome Hybrid Nanoplatform Enables Pyroptosis-Enhanced Immune Reprogramming in Glioblastoma. (PubMed, ACS Nano) - Jul 18, 2026 - "Driven by bioinformatics analysis identifying epidermal growth factor receptor (EGFR) and caspase-3 as key regulators of an immune-evasive pyroptosis pathway, we screened natural compounds and identified quercetin (Q) and chlorogenic acid (C) as dual-targeting agents, thereby laying a therapeutic foundation for amplifying pyroptosis in GBM treatment...Moreover, this treatment strategy can significantly inhibit the distant tumors in the primary-distal orthotopic GBM model. This study proposes a strategy for the precise immunotherapy of GBM by exploiting natural products to target overexpressed GSDME and induce the pyroptotic cascade."
Journal • Brain Cancer • Glioblastoma • Oncology • Solid Tumor • CASP3 • CASP8 • GSDME
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Jie Bian; Liming Miao; Ru Zhao; Wang Yu; Wei Song; Xiaoyu Zhao; Xiue Jiang; Yiyao Zhou; Yue Wang
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