Skin-lightening metabolites in Achillea filipendulina: comparative phytochemical and bioactivity profiling of extracts from shoot cultures and field-grown plants. (PubMed, Planta Med) - Jul 14, 2026 - "At the same time, quantitative analysis by LC-MS confirmed that chlorogenic acid was the major compound, reaching the highest concentrations in AFH and AFB ethanol based extracts...Cytotoxicity testing showed that AFH extracts reduced HaCaT viability by 25-38%, while AFiv and AFB were non-cytotoxic and exhibited reduced or no cytotoxicity toward melanoma cells. Moreover, technological validation of the most potent AFiv 50EtOH extract within model O/W and W/O emulsions demonstrated exceptional 30-day physicochemical stability and compatibility."
Journal • Melanoma • Oncology • Solid Tumor • Tyrosinase
|
|
Agnieszka Szopa; Karolina Czech; Wirginia Anna Kukula-Koch
|