A dual-responsive self-healing injectable hydrogel loaded with Isatis root-derived carbon dots toward efficient infected wound therapy. (PubMed, Int J Biol Macromol) - Jul 2, 2026 - "Oxidized pullulan (OPu) was used to fabricate the hydrogel, and the bioactive polyphenol chlorogenic acid (CA) acted as the crosslinking agent...Both in vitro and in vivo evaluations confirmed that the hydrogel was highly biocompatible and provided anti-infective, anti-oxidative, and anti-inflammatory effects during the early stages of healing, followed by an increase in angiogenesis and acceleration of the wound healing process. The hydrogel developed in this study is versatile and can serve as a promising and effective biomaterial platform for managing bacteria-infected wounds."
Journal • Inflammation
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Jinjing Xu; Jiwei Wang; Mingkang Yang; Niuniu Zhang; Pengqian Zhou; Yajuan Chen; Yan Chen; Yifan Ouyang
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