Casticin From Sanse Powder- In Vitro Release Medium Inhibits FAK/PI3K/AKT Phosphorylation Reducing Synovial Senescence and Alleviates Inflammation in Knee Osteoarthritis. (PubMed, J Cell Mol Med) - Oct 13, 2026 - "UHPLC-MS/MS identified CAS, monocerin, and chlorogenic acid as major components...Additional experiments demonstrated that CAS alleviates KOA-related inflammation and cellular senescence by inhibiting FAK/PI3K/AKT phosphorylation. These findings indicate that CAS in SSP-IVRM reduces synovial fibroblast senescence and inflammation through inhibition of the FAK/PI3K/AKT signalling pathway, thereby exerting therapeutic effects against KOA."
Journal • Preclinical • Fibrosis • Immunology • Inflammation • Osteoarthritis • Pain • Rheumatology
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Deren Liu; Houyu Fu; Jiangyu Liu; Jun Mao; Lei Shi; Lishi Jie; Peimin Wang; Peng Wu; Rui Jiang; Songjiang Yin; Yibao Wei
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