Chlorogenic acid promotes macrophage phagocytosis through the METTL3-SIRPA axis in an m6A-dependent manner for colon cancer therapy. (PubMed, Biochem Pharmacol) - Jun 26, 2026 - "METTL3 increases the mRNA stability of the intrinsic immune checkpoint SIRPA by activating IGF2BP2 in an m6A-dependent manner, which subsequently increases its protein expression and suppresses the phagocytosis of macrophages both in vivo and in vitro. In conclusion, CHA is a candidate inhibitor compound that targets the METTL3-SIRPA axis through enhancing the phagocytic function of macrophages and is thus a promising therapy for treating colon cancer."
Journal • Colon Cancer • Colorectal Cancer • Oncology • Solid Tumor • IGF2BP2 • METTL3 • SIRPA
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Bolin Zhang; Dongxu Lu; Enjia Zhou; Fang Wang; Guodong Tang; Jing Jin; Mengyao Hao; Mingchao Wang; Shuying Li; Wenhao Ju; Wenjing Zhang; Xinyu Li; Yiran Chen; Zeyu Xing
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