Therapeutic potential of phenolic acids in bone tissue healing and regeneration: a scoping review. (PubMed, Nutr Res) - Jun 24, 2026 - "Caffeic acid (CAPE), chlorogenic acid, and ferulic acid stimulated osteoblast proliferation and differentiation, enhanced mineralization and osteogenic gene expression, and inhibited osteoclastogenesis and inflammatory pathways...However, current evidence remains predominantly preclinical, and translation to humans may be influenced by factors such as dietary intake, bioavailability, metabolism, and long-term exposure. Therefore, well-designed clinical and nutritional studies are needed to validate their efficacy and translational applicability in human bone health."
Journal • Review • Osteoporosis
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Cristiane Duque; Gabriel Pereira Nunes; Geórgia Rondó Peres; Haylla de Faria Horta; Priscila Toninatto Alves de Toledo; Renata de Oliveira Alves; Tamires Passadori Martins
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