Injectable Composite Hydrogels Orchestrating Macrophage Reprogramming and Chondrogenesis to Promote Microfracture-Assisted Cartilage Repair. (PubMed, Adv Healthc Mater) - Jun 23, 2026 - "Here, an injectable, thermosensitive composite hydrogel, constructed from a dopamine-modified hyaluronic acid and Pluronic F127 network, which incorporates chlorogenic acid (CA) and ZIF-8 nanoparticles encapsulated with kartogenin (KGN), is developed to establish a cascade repair strategy...Furthermore, this composite hydrogel, combined with MF, improves cartilage tissue regeneration in a rat model, as evidenced by smooth defect filling, well-organized extracellular matrix deposition, and reduced Matrix metalloproteinase 13-mediated degradation. This work presents a synergistic immuno-chondroregenerative platform that overcomes fundamental limitations of MF and offers a promising paradigm for functional cartilage regeneration."
Journal • Musculoskeletal Diseases • MMP13
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Bowen Xu; Changshun Huang; Meng Zhang; Minghui Wang; Peng Du; Runxiao Zheng; Shuai Gao; Xinyi Zhang; Yanzi Liu
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