Integrative single-cell transcriptomics and experimental validation reveal that Tusizi Formula ameliorates premature ovarian insufficiency by preserving the primordial follicle pool and promoting granulosa cell differentiation. (PubMed, Tissue Cell) - Oct 10, 2026 - "Our data demonstrate that TSZF and its active components mitigate TG-induced ovarian injury through modulation of the ovarian microenvironment, preservation of the primordial follicle pool, promotion of GC differentiation, and enhancement of GC-oocyte communication, with INHBA identified as a key regulatory node. These findings support a protective and recovery‑associated role of TSZF in POI."
Journal • Ophthalmology • Women's Health • CYP19A1
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Annika Smith; Huiting Cheng; Jianying Kang; Joshua Johnson; Li Guo; Siqi Li; Ying Xu; Yuan Li; Zehui Li
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