Evaluation of antitrichomonal activity of coffeewaste compounds against different Trichomonas vaginalis strains: An in vitro and in silico study. (PubMed, Microb Pathog) - Oct 10, 2026 - "For this, caffeine, chlorogenic acid, quinic acid, caffeic acid, and mangiferin were tested in vitro for their anti-T...Their exact mechanism of action still remains unclear, although TEM and molecular docking results may orientate next steps regarding autophagy alterations and LDH interaction, respectively. We highlight that coffee-derived compounds should be considered as drug candidates for trichomoniasis, presenting promising agents with potential for further preclinical evaluation."
Journal • Preclinical • Infectious Disease
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Ana Claudia Chagas de Paula; Anna De Freitas; Fernanda Maria Pinto Vilela; Humberto Moreira Hungaro; Laura Gonçalves Rezende; Lauren Hubert Jaeger; Victor Midlej; Vinicius Gonçalves Maltarollo; Wanderleya Toledo Dos Santos
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