Comprehensive chemical characterization of quanduzhong capsules and In Vivo profiling of parent constituents and metabolites in rats by UPLC-Q-TOF-MSE. (PubMed, J Pharm Biomed Anal) - Sep 20, 2026 - "Furthermore, 35 metabolites derived from five representative constituents, including geniposide, geniposidic acid, aucubin, pinoresinol di-O-glucopyranoside, and chlorogenic acid, were identified or tentatively characterized, involving major biotransformation pathways such as deglycosylation, hydrolysis, oxidation/reduction, methylation, glucuronidation, and sulfation. This study provides a comprehensive chemical and metabolic dataset for Quanduzhong Capsules and establishes an efficient analytical workflow for the systematic characterization and exposure evaluation of Eucommia ulmoides-based preparations. These findings highlight the selective in vivo exposure of key constituents and provide insight into the exposure-related material basis of Quanduzhong Capsules."
Journal • Preclinical
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Cui Li; Dong Bai; Mengru Cai; Mengya Dang; Mingkai Yao; Na Zhang; Yuping Wang; Zhengshen Yan
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