A top-down approach for integrative analysis of vinegar processing effects on Cyperi Rhizoma. (PubMed, J Chromatogr B Analyt Technol Biomed Life Sci) - Oct 1, 2026 - "After integrating chemical and bioactive information, eleven chemical compounds (including tryptophan, chlorogenic acid, catechin, epicatechin, protocatechuic aldehyde, protocatechuic acid, cyperenone, α-cyperone, 4-coumaric acid, ferulic acid and luteolin) are identified as vinegar-processing chemical markers (VP markers) of CR based on UHPLC-Q-TOF-MS combing with UHPLC-QQQ-dMRM-MS/MS...Furthermore, vinegar processing optimized by Box-Behnken design-response surface methodology (BBD-RSM) significantly enhances the anti-hepatic fibrosis efficacy of CR, reversing CCl4-induced abnormalities in liver function (ALT, AST, LDH), fibrotic progression (α-SMA, Tgfb1, Col1a1), and plasma metabolites (lysoPCs, PCs, steroids, etc) in rats. This study is meaningful for exploring the therapeutic substances of CR and promoting its further development."
Journal • Fibrosis • Hepatology • Immunology • COL1A1 • TGFB1
|
|
Fanjiao Zuo; Huining Geng; Huizi Ouyang; Jun He; Lu Chen; Peng Zhao; Xueyu Liu; Yameng Zhu; Ye Shang
|