Chlorogenic Acid Attenuates Liver Fibrosis in Mice via HIF-1α Inhibition and M2 Macrophage Polarization. (PubMed, Curr Med Chem) - Oct 2, 2026 - "This study demonstrates that CGA effectively reverses CCl4-induced liver fibrosis by promoting macrophage polarization toward the M2 phenotype, which in turn facilitates the elimination of HSCs. Its ability to reprogram macrophage function underscores its potential for clinical translation in treating chronic liver fibrosis."
Journal • Preclinical • Fibrosis • Hepatology • Immunology • Inflammation • Liver Cirrhosis • Liver Failure • HIF1A • MRC1
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Die Shi; Jun Li; Ling Feng; Ting Tang; Yiying Yang; Yongqin Zhang
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