Sprayable Integrated Hydrogel for Synergistic Alleviation of Oxidative Stress in Atopic Dermatitis Treatment. (PubMed, ACS Appl Mater Interfaces) - Sep 17, 2026 - "This nanoparticle was a cyclodextrin metal-organic framework (P-M@CA) loaded with chlorogenic acid (CA) and surface-modified with polydopamine (PDA)...The C/O/P hydrogel dramatically decreased epidermal thickening, inhibited mast cell infiltration, downregulated the key inflammatory factor thymic stromal lymphopoietin (TSLP), and lowered serum immunoglobulin E (IgE) levels in an AD mouse model established by induction with 1-chloro-2,4-dinitrobenzene (DNCB). In summary, C/O/P hydrogels effectively clear reactive oxygen species and regulate the oxidative stress microenvironment, offering a promising local delivery strategy for AD treatment."
Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • TSLP
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Fuchen Jiang; Huacheng Tang; Jun Lu; Shengxin Su; Shuang Liu; Xiao Zhou; Xiaoli Pan; Xiaomin Lai; Yaxuan He; Ying Wang; Yingxi Li; Yun Duan; Zhen Huang
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