A Microneedle Platform Co-loaded with Eugenol, Chlorogenic Acid, and Allopurinol for In Vivo Modulation of Pathological Crystal Formation in Experimental Gouty Arthritis. (PubMed, ACS Appl Mater Interfaces) - Sep 16, 2026 - "Synovial IL-1β, IL-6, and TNF-α positive areas were all below 5% in the MN-treated group and were significantly lower than those in untreated rats (n = 3, all P < 0.0001), accompanied by improved synovial tissue integrity. This study provides in vivo experimental evidence that pathological MSU crystallization can be locally modulated through an interfacial-engineered MN platform, offering a new strategy for gout therapy by integrating crystal regulation, anti-inflammatory intervention, and urate-lowering treatment."
Journal • Preclinical • Gout • Immunology • Inflammation • Inflammatory Arthritis • Rheumatology • IL1B • IL6 • TNFA
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Desen Wang; Jianjun Zhang; Jiaqi Liu; Lianwen Qi; Peiya Shen; Shuai Qian; Yuan Gao; Yuanfeng Wei; Yutong Song
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