Mechanistic Insights into Polyphenol Oxidase Inhibition by Four Bioactive Constituents from Hydrangea macrophylla Serrata: Antioxidant Activity of Single Compounds Compared to the Whole-Leaf Extract. (PubMed, Molecules) - Oct 17, 2026 - "In this study, from an extract of tea-hortensia leaves, we isolated and structurally characterized four major constituents: chlorogenic acid (CGA, 5-caffeoylquinic acid), hydrangenol (HG), hydrangeic acid (HGA), and phyllodulcin (PD)...These findings provide a systematic comparative assessment of the anti-browning mechanisms of the major constituents of H. macrophylla serrata, highlighting the potential of this plant as a natural source of antioxidants and anti-browning agents for food applications. The integration of biochemical kinetics, copper-chelating analysis, and in silico docking offers a comprehensive mechanistic framework for understanding PPO inhibition by natural phenolic compounds."
Journal • Allergy • Immunology
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Sijie Mei; Thomas Heymann; Volker Böhm
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