Synergistic Orchestration of Chlorogenic Acid Analogs in Sugarcane Molasses Polyphenols for Sucrase Inhibition: Insights into a Multilevel Inhibitory Mechanism. (PubMed, Foods) - Sep 27, 2026 - "Mechanistically, CA and NA exhibited competitive inhibition, whereas MC and SMPE showed mixed-type inhibition; fluorescence, CD, and thermal stability analyses revealed compound-dependent changes in aromatic residue microenvironments, secondary structure, and protein stability, while molecular modeling predicted peripheral binding of CA/NA and catalytic-region interactions of MC, suggesting distinct but complementary routes for perturbing substrate recognition and catalysis. This study provides mechanistic insight into the synergistic inhibition of sucrase by SMPE and supports its potential development as a natural agent for modulating postprandial glycemia."
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Chengfeng Zhang; He Li; Jiulong An; Lu Li; Matthew Flavel; Shenghong Yao; Wanlu Liu; Yanv Zhou; Yumei Wang
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