Chlorogenic acid promotes mtDNA leakage to enhance cGAS-STING induced anti-tumor immunity via ATF5-mtHSP70-TFAM system. (PubMed, Int J Biol Sci) - Sep 5, 2026 - "In a mouse model, ATF5 knockout enhances cGAS/STING signaling and subsequent immune responses, leading to tumor growth inhibition. These results highlight a novel role of CGA in regulating mitochondrial-associated proteins, positioning it as a potential therapeutic strategy for cancer via the mtDNA-cGAS-STING pathway."
Journal • Oncology • ATF5 • HSPA9 • STING • TFAM
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Chu-Juan Hu; Ge Si; Jian-Dong Jiang; Jie Zhang; Jin-Jin Cui; Ling Ren; Lu-Lu Wang; Ping Zhou; Rui Li; Wen-Bin Li; Yan-Xing Han; Ying-Ying He
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