SPR-based screening identifies luteolin from Artemisia scoparia as a potential PBP2a inhibitor with β-lactam-potentiating activity against MRSA. (PubMed, Phytomedicine) - Sep 3, 2026 - "Luteolin is a potential PBP2a-targeting compound with β-lactam-potentiating activity against MRSA. Its effects may involve PBP2a interaction and broader metabolic and regulatory perturbations, although direct inhibition of PBP2a enzymatic activity remains unconfirmed."
Journal • Infectious Disease
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Dandan Zhang; Doudou Yang; Guanjie Zhao; Qian Li; Ruoliang Wang; Xu Liu; Yawen Gao; Yinku Liang; Yuhang Tang
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