Discovery of N-(2-chloro-5-(3-(pyridin-4-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide (FD274) as a highly potent PI3K/mTOR dual inhibitor for the treatment of acute myeloid leukemia.

dactolisib (RTB101) - Adicet Bio

http://www.ncbi.nlm.nih.gov/pubmed/37329712

Chengbin Yang; Jianxin Wang; Mingli Deng; Tianze Wu; Xiaofeng Liu; Yaming Zhou; Yi Chen; Yongtai Yang; Yu Jia; Yun Ling; Yunjian Gao

Jun 18, 2023