[VIRTUAL] Interplay between PI3K/mTOR Signaling and IRE1a-XBP1 Promotes Survival of Pre-B NRASG12D all Cells Providing a Therapeutic Vulnerability for the “Undruggable” Driver RAS

mirdametinib (PD-0325901) - SpringWorks Therap, BeiGene

dactolisib (RTB101) - resTORbio

https://ash.confex.com/ash/2020/webprogram/Paper140299.html

Iris Appelmann, MD1; Azam Salimi1; Michael Huber, PhD2; Mirle Schemionek, PhD3; Margherita Vieri, PhD4; Tim H Brümmendorf, MD5; John B. Patterson6; Behzad Kharabi Masouleh, MD7

Nov 5, 2020