CHK1 inhibition by prexasertib sensitizes cisplatin-resistant malignant tumor cells via checkpoint abrogation and STAT1-driven PD-L1 upregulation.

prexasertib (ACR-368) - Acrivon Therap

cisplatin - Generic mfg.

http://www.ncbi.nlm.nih.gov/pubmed/41477994

Chao Rong; Fang Xiang; Jinjin Zhang; Jinsha Wang; Qiong Zhang; Ting Wang; Yao Hu; Ziyu Zhang

Jan 2, 2026