SLC35F2 in Cancer Development and Progression. (PubMed, J Cell Physiol) - Oct 7, 2026 - "Recent studies have identified SLC35F2 as the only currently known queuosine (Q)-specific transporter in human cells and as the principal high-affinity transporter of queuine (q), although it is not the absolutely exclusive route for q uptake...Using a structured narrative-review approach, this article critically evaluates the structure and localization of SLC35F2, q/Q transport, regulation of its expression and protein stability, tumor-associated functions, and YM155 delivery. It distinguishes replicated mechanisms from findings supported by single studies and from testable hypotheses, thereby providing a framework for future mechanistic research and precision drug delivery."
Journal • Review • Oncology • SLC35F2
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Anjie Chen; Chen Guo; Chenwei Gu; Si Shen; Sixi Li; Yuanyuan Mi; Zhonghao Tang
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